Solid tumors are complex organ-like structures that consist not only of tumor cells but also of
vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor …

Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

The extracellular matrix (ECM) is an important component of the tumor microenvironment
(TME), having several important roles related to the hallmarks of cancer. In cancer, multiple …

Negatively charged tissues are ubiquitous in the human body and are associated with a
number of common diseases yet remain an outstanding challenge for targeted drug delivery …

Sulfation is a dynamic and complex posttranslational modification process. It can occur at
various positions within the glycosaminoglycan (GAG) backbone and modulates …

Glycosaminoglycans are natural heteropolysaccharides that are present in every
mammalian tissue. They are composed of repeating disaccharide units that consist of either …

One of the major challenges in applying nanomedicines to cancer therapy is their low
interstitial diffusion in solid tumors. Although the modification of nanocarrier surfaces with …

The use of tissue-engineered 3D models of cancer has grown in popularity with recent
advances in the field of cancer research. 3D models are inherently more biomimetic …

The characteristic molecular composition of the different glycosaminoglycans (GAGs) is
related to their role as structural components and regulators of a multitude of functions of …

It is becoming increasingly clear that signals generated in tumor microenvironments are
crucial to tumor cell behavior, such as survival, progression and metastasis. The …