Powder production and particle engineering for dry powder inhaler formulations
Dry powder inhalers have become increasingly attractive for pulmonary delivery of locally
and systemically effective medications. In comparison to the liquid counterparts, such as …
and systemically effective medications. In comparison to the liquid counterparts, such as …
Evaluating UiO-66 metal–organic framework nanoparticles as acid-sensitive carriers for pulmonary drug delivery applications
Develo** novel drug carriers for pulmonary delivery is necessary to achieve higher
efficacy and consistency for treating pulmonary diseases while limiting off-target side effects …
efficacy and consistency for treating pulmonary diseases while limiting off-target side effects …
[HTML][HTML] Additive manufacturing in respiratory sciences–Current applications and future prospects
Additive Manufacturing (AM) comprises a variety of techniques that enable fabrication of
customised objects with specific attributes. The versatility of AM procedures and constant …
customised objects with specific attributes. The versatility of AM procedures and constant …
Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells
Engineered nanoparticles have the potential to expand the breadth of pulmonary
therapeutics, especially as respiratory vaccines. Notably, cationic nanoparticles have been …
therapeutics, especially as respiratory vaccines. Notably, cationic nanoparticles have been …
Polymeric nanoparticles
Polymers, a diverse class of materials composed of repeating units called monomers, are an
essential tool of drug delivery. Polymer nanoparticles may possess a wide variety of …
essential tool of drug delivery. Polymer nanoparticles may possess a wide variety of …
Realizing Lobe-Specific Aerosol Targeting in a 3D-Printed In Vitro Lung Model
Background: Delivery of aerosols to isolated lobes of the lungs would be beneficial for
diseases that have lobe-specific effects, such as cancer, pneumonia, and chronic obstructive …
diseases that have lobe-specific effects, such as cancer, pneumonia, and chronic obstructive …
Distribution and cellular uptake of PEGylated polymeric particles in the lung towards cell-specific targeted delivery
Purpose We evaluated the role of a poly (ethylene glycol)(PEG) surface coating to increase
residence times and alter the cellular fate of nano-and microparticles delivered to the lung …
residence times and alter the cellular fate of nano-and microparticles delivered to the lung …
Formulation of high-performance dry powder aerosols for pulmonary protein delivery
Purpose Pulmonary delivery of biologics is of great interest, as it can be used for the local
treatment of respiratory diseases or as a route to systemic drug delivery. To reach the full …
treatment of respiratory diseases or as a route to systemic drug delivery. To reach the full …
Age-dependent changes in phagocytic activity: in vivo response of mouse pulmonary antigen presenting cells to direct lung delivery of charged PEGDA nanoparticles
ER Sudduth, A López Ruiz… - Journal of …, 2024 - Springer
Background Current needle-based vaccination for respiratory viruses is ineffective at
producing sufficient, long-lasting local immunity in the elderly. Direct pulmonary delivery to …
producing sufficient, long-lasting local immunity in the elderly. Direct pulmonary delivery to …
Pulmonary delivery of butyrylcholinesterase as a model protein to the lung
Pulmonary delivery has great potential for delivering biologics to the lung if the challenges of
maintaining activity, stability, and ideal aerosol characteristics can be overcome. To study …
maintaining activity, stability, and ideal aerosol characteristics can be overcome. To study …