Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Schistosomiasis, a major neglected tropical disease, affects more than 250 million people
worldwide. Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel …

Praziquantel (PZQ) is an essential medicine for treating parasitic flatworm infections such as
schistosomiasis, which afflicts over 250 million people. However, PZQ is not universally …

Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

In September 2022, the Drug Discovery Unit at the University of Dundee, UK, organised an
international meeting at the Wellcome Collection in London to explore the current clinical …

Drug discovery for schistosomiasis is still limited to a handful of academic laboratories
worldwide, with only a few novel antischistosomal lead compounds being actively …

Praziquantel (PZQ) is the drug of choice for the treatment of all forms of schistosomiasis,
although its mechanisms of action are not completely understood. PZQ acts largely on adult …

The drug praziquantel (PZQ) is the key clinical therapy for treating schistosomiasis and other
infections caused by parasitic flatworms. A schistosome target for PZQ was recently …

Schistosomiasis, a neglected tropical disease provoked by infection with parasitic blood
flukes of the genus Schistosoma, affects almost 240 million people worldwide, and more …

An efficient deracemization method for conversion of the racemate to the desirable (R)‐
enantiomer of Praziquantel has been developed by coupling incompatible racemization and …