Lipid droplet functions beyond energy storage

MA Welte, AP Gould - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2017 - Elsevier
Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important
for energy metabolism. Their function in energy storage is firmly established and …

Caleosin/Peroxygenases: multifunctional proteins in plants

A Hanano, E Blée, DJ Murphy - Annals of Botany, 2023 - academic.oup.com
Abstract Background Caleosin/peroxygenases (CLO/PXGs) are a family of multifunctional
proteins that are ubiquitous in land plants and are also found in some fungi and green …

Mammalian lipid droplets: Structural, pathological, immunological and anti-toxicological roles

N Hammoudeh, C Soukkarieh, DJ Murphy… - Progress in lipid …, 2023 - Elsevier
Mammalian lipid droplets (LDs) are specialized cytosolic organelles consisting of a neutral
lipid core surrounded by a membrane made up of a phospholipid monolayer and a specific …

Insights into the control of taxane metabolism: Molecular, cellular, and metabolic changes induced by elicitation in Taxus baccata cell suspensions

E Perez-Matas, A Hanano, E Moyano… - Frontiers in Plant …, 2022 - frontiersin.org
More knowledge is needed about the molecular/cellular control of paclitaxel (PTX)
production in Taxus spp. cell cultures. In this study, the yield of this anticancer agent in …

Characterization of lipid droplets from a Taxus media cell suspension and their potential involvement in trafficking and secretion of paclitaxel

A Hanano, E Perez-Matas, M Shaban, RM Cusido… - Plant cell reports, 2022 - Springer
Key message Our paper describes the potential roles of lipid droplets of Taxus media cell
suspension in the biosynthesis and secretion of paclitaxel and, therefore, highlights their …

Dioxin impacts on lipid metabolism of soil microbes: towards effective detection and bioassessment strategies

S Mahfouz, G Mansour, DJ Murphy… - Bioresources and …, 2020 - Springer
Dioxins are the most toxic known environmental pollutants and are mainly formed by human
activities. Due to their structural stability, dioxins persist for extended periods and can be …

Evolutionary and genomic analysis of the caleosin/peroxygenase (CLO/PXG) gene/protein families in the Viridiplantae

F Rahman, M Hassan, R Rosli, I Almousally… - PLoS …, 2018 - journals.plos.org
Bioinformatics analyses of caleosin/peroxygenases (CLO/PXG) demonstrated that these
genes are present in the vast majority of Viridiplantae taxa for which sequence data are …

Lipid Droplets in Aquatic Animals: Diversity, Biogenesis, and Functional Implications

S Zhu, Z Lv, Q Ai, C Li - Reviews in Aquaculture, 2025 - Wiley Online Library
Amid the aquaculture boom, chemical contaminants, diseases, and improper nutrition
persist as threats to the sustainability of aquaculture. The accumulation of lipid droplets in …

Identification of a dioxin-responsive oxylipin signature in roots of date palm: involvement of a 9-hydroperoxide fatty acid reductase, caleosin/peroxygenase PdPXG2

A Hanano, M Shaban, I Almousally, DJ Murphy - Scientific reports, 2018 - nature.com
Dioxins are highly hazardous pollutants that have well characterized impacts on both animal
and human health. However, the biological effects of dioxins on plants have yet to be …

Encapsulation of paclitaxel into date palm lipid droplets for enhanced brain cancer therapy

A Yousfan, N Moursel, A Hanano - Scientific Reports, 2024 - nature.com
Paclitaxel, a powerful anticancer drug, is limited by its poor water solubility and systemic
toxicity, which hinder its effectiveness against aggressive brain tumors. This study aims to …