Methyl-CpG binding protein 2 (MeCP2) was first identified in 1992 as a protein that binds
specifically to methylated DNA. Mutations in the MECP2 gene were later found to be the …

Two severe, progressive neurological disorders characterized by intellectual disability,
autism, and developmental regression, Rett syndrome and MECP2 duplication syndrome …

Despite past extensive studies, the mechanisms underlying pulmonary fibrosis (PF) still
remain poorly understood. Here, we demonstrated that lungs originating from different types …

Gait and posture are often perturbed in many neurological, neuromuscular, and
neuropsychiatric conditions. Rodents provide a tractable model for elucidating disease …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by altered social
interaction and communication, and repetitive, restricted, inflexible behaviors. Approximately …

Rare diseases are very difficult to study mechanistically and to develop therapies for
because of the scarcity of patients. Here, the rare neuro-metabolic disorder Rett syndrome …

Rett syndrome (RTT) is a severe genetic disorder resulting from mutations in the X-linked
MECP2 gene. MeCP2 protein is highly expressed in the nervous system and deficiency in …

Neurological diseases particularly Alzheimer's disease (AD), Parkinson's disease (PD),
stroke, and epilepsy are on the rise all around the world causing morbidity and mortality …

Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for
which there is no effective treatment. Here we provide evidence that activation of …

Abstract Loss of MeCP2 (Methyl CpG binding protein 2) in Rett syndrome (RTT) causes
brain weight decrease, shrinkage of the cortex with reduced dendritic arborization …