Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …

Furin catalyses a simple biochemical reaction—the proteolytic maturation of proprotein
substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and …

Stimulator of interferon genes (STING) is essential for the type I interferon response against
DNA pathogens. In response to the presence of DNA and/or cyclic dinucleotides, STING …

THE definition of cellular organelles has evolved over the last hundred years largely driven
by morphologic observations, but more recently has been supplemented and complemented …

Recent advances have uncovered the general protein apparatus used by all eukaryotes for
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of …

New textbooks at all levels of chemistry appear with great regularity. Some fields like basic
biochemistry, organic reaction mechanisms, and chemical thermody namics are well …

Cytotoxic T lymphocytes (CTL) contain granules that are exocytosed during specific
interaction with target cells (TC). In this process, the granule contents, including the lethal …

Collagen fibrils in the extracellular matrix allow connective tissues such as tendon, skin and
bone to withstand tensile forces. The fibrils are indeterminate in length, insoluble and form …

Using a selection for spontaneous mutants that mislocalize a vacuolar carboxypeptidase Y
(CPY)-invertase fusion protein to the cell surface, we identified vacuolar protein targeting …

Many viruses have membrane glycoproteins that are activated at cleavage sites containing
multiple arginine and lysine residues by cellular proteases so far not identified. The …