Since their inception, genome-wide association studies (GWAS) have identified more than a
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …

Genome-wide association studies (GWAS) have revolutionized our understanding of the
genetic architecture of complex traits and diseases. GWAS summary statistics have become …

Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection
remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited …

Transcriptome-wide association study (TWAS) is an important integrative method for
identifying genes that are causally associated with phenotypes. A key step of TWAS involves …

Understanding the genetic regulatory mechanisms of gene expression is an ongoing
challenge. Genetic variants that are associated with expression levels are readily identified …

Combining individual p-values to perform an overall test is often encountered in statistical
applications. The Cauchy combination test (CCT)(Journal of the American Statistical …

Background Detecting trans-ethnic common associated genetic loci can offer important
insights into shared genetic components underlying complex diseases/traits across diverse …

Background Clinical and epidemiological studies have suggested systemic lupus
erythematosus (SLE) and rheumatoid arthritis (RA) are comorbidities and common genetic …

Introduction Ultradense peptide binding arrays that can probe millions of linear peptides
comprising the entire proteomes of human or mouse, or hundreds of thousands of microbes …

Genome-wide association studies (GWAS) have identified multiple causal genes associated
with amyotrophic lateral sclerosis (ALS); however, the genetic architecture of ALS remains …