Pacemaking is a basic physiological process, and the cellular mechanisms involved in this
function have always attracted the keen attention of investigators. The “funny”(I f) current …

Equations have been developed to describe cardiac action potentials and pacemaker
activity. The model takes account of extensive developments in experimental work since the …

1. A mathematical model of membrane action potentials of mammalian ventricular
myocardial fibres is described. The reconstruction model is based as closely as possible on …

Pyramidal cells in the CA1 field of guinea pig hippocampal slices were voltage-clamped
using a single microelectrode, at 23–30° C. Small inwardly relaxing currents triggered by …

1. The electrical activity of Cardiac Purkinje fibres was reconstructed using a mathematical
model of the membrane current. The individual components of ionic curent were described …

Individual cells were isolated from the sino‐atrial node area of the rabbit heart using an
enzyme medium containing collagenase and elastase. After enzymatic treatment the cells …

First described over a quarter of a century ago, the cardiac pacemaker “funny”(If) current has
been extensively characterized since, and its role in cardiac pacemaking has been …

Inward-rectifier potassium (K+) channels conduct K+ ions most efficiently in one direction,
into the cell. Kir2 channels control the resting membrane voltage in many electrically …

From the Department of Physiology and Biophysics, University of Washington School of
Medicine, Seattle, Washington 98195. Dr. Schwarz's present address is I Physiologisches …

Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol
dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug …