Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell–cell interactions in the pathophysiology of neurological disease
Neuroserpin is an axonally secreted serpin that is involved in regulating plasminogen and
its enzyme activators, such as tissue plasminogen activator (tPA). The protein has been …
its enzyme activators, such as tissue plasminogen activator (tPA). The protein has been …
Disruption of the ubiquitin-proteasome system and elevated endoplasmic reticulum stress in epilepsy
S Poliquin, JQ Kang - Biomedicines, 2022 - mdpi.com
The epilepsies are a broad group of conditions characterized by repeated seizures, and
together are one of the most common neurological disorders. Additionally, epilepsy is …
together are one of the most common neurological disorders. Additionally, epilepsy is …
Physiological and pathological functions of neuroserpin: regulation of cellular responses through multiple mechanisms
It is 27 years since neuroserpin was first discovered in the nervous system and identified as
a member of the serpin superfamily. Since that time potential roles for this serine protease …
a member of the serpin superfamily. Since that time potential roles for this serine protease …
Icariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apoptosis
F Li, B Gao, H Dong, J Shi, D Fang - PloS one, 2015 - journals.plos.org
By suppressing neuronal apoptosis, Icariin is a potential therapeutic drug for neuronal
degenerative diseases. The molecular mechanisms of Icariin anti-apoptotic functions are still …
degenerative diseases. The molecular mechanisms of Icariin anti-apoptotic functions are still …
Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB
NA Guadagno, C Moriconi, V Licursi, E D'Acunto… - Neurobiology of …, 2017 - Elsevier
The serpinopathies are human pathologies caused by mutations that promote
polymerisation and intracellular deposition of proteins of the serpin superfamily, leading to a …
polymerisation and intracellular deposition of proteins of the serpin superfamily, leading to a …
Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB
E D'Acunto, L Gianfrancesco, I Serangeli… - Cellular and Molecular …, 2022 - Springer
The neurodegenerative condition FENIB (familiar encephalopathy with neuroserpin
inclusion bodies) is caused by heterozygous expression of polymerogenic mutant …
inclusion bodies) is caused by heterozygous expression of polymerogenic mutant …
[HTML][HTML] The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin
Abstract α 1-Antitrypsin is a serine protease inhibitor produced in the liver that is responsible
for the regulation of pulmonary inflammation. The commonest pathogenic gene mutation …
for the regulation of pulmonary inflammation. The commonest pathogenic gene mutation …
New concepts in alpha-1 antitrypsin deficiency disease mechanisms
Alpha-1 antitrypsin deficiency is predominantly caused by point mutations that alter the
protein's folding. These mutations fall into two broad categories: those that destabilize the …
protein's folding. These mutations fall into two broad categories: those that destabilize the …
UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer
Y Tian, R Dong, Y Guan, Y Wang, W Zhao… - Journal of Translational …, 2025 - Springer
Background Immune cells within tumor tissues play important roles in remodeling the tumor
microenvironment, thus affecting tumor progression and the therapeutic response. The …
microenvironment, thus affecting tumor progression and the therapeutic response. The …
Interactions between N‐linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum
The neuronal serpin neuroserpin undergoes polymerisation as a consequence of point
mutations that alter its conformational stability, leading to a neurodegenerative dementia …
mutations that alter its conformational stability, leading to a neurodegenerative dementia …