Highlights•Protein–protein interactions are essential for almost all cell processes.•Peptides
are ideal candidates for targeting protein–protein interactions (PPIs).•We survey screening …

Highlights•Structure-based strategies allow more-specific targeting of protein–protein
interactions (PPIs).•Interfering peptides (IPs) become a promising alternative to small …

Mitochondria are dynamic organelles that exchange contents and undergo remodelling
during cyclic fusion and fission. Genetic mutations in MFN2 (the gene encoding mitofusin 2) …

Highlights•Cyclic peptides are ideal inhibitors of protein–protein interactions (PPIs), due to
low immunogenicity and large surface area.•Peptide libraries are excellent tools to screen …

Protein kinases are one of the most significant drug targets in the human proteome,
historically harnessed for the treatment of cancer, cardiovascular disease, and a growing …

As biological research has synthesized genomics, proteomics, metabolomics, and
transcriptomics into systems biology, a new multiomics approach to biological research has …

We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in
failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on …

Metabolism is reprogrammed in a variety of cancer cells to ensure their rapid proliferation.
Cancer cells prefer to utilize glycolysis to produce energy as well as to provide large …

Human protein kinases are highly-sought-after drug targets, historically harnessed for
treating cancer, cardiovascular disease, and an increasing number of autoimmune and …

Cellular senescence is a fundamental cell fate playing a significant role throughout the
natural aging process. However, the molecular determinants distinguishing senescence …