The discovery of novel synthetic compounds with drug-like properties is an ongoing
challenge in medicinal chemistry. Natural products have inspired the synthesis of …

An overview of pyrroles as distinct scaffolds with therapeutic potential and the significance of
pyrrole derivatives for drug development are provided in this article. It lists instances of …

Erratic cell proliferation is the initial symptom of cancer, which can eventually metastasize to
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …

Abstract Pyrrolo [2, 3-d] pyrimidine-based kinase inhibitors have emerged as an important
class of targeted therapeutics to combat various types of cancer. The distinctive structural …

Neurotrophic receptor kinase (NTRK) fusions are actionable oncogenic drivers of multiple
pediatric and adult solid tumors, and tropomyosin receptor kinase (TRK) has been …

This report summarizes the latest published data on the antiproliferative action and cytotoxic
activity of Mannich bases, a structurally heterogeneous category of chemical entities that …

Discoidin domain receptor 1 (DDR1) kinase has emerged as a promising target for cancer
therapy, and selective DDR1 inhibitors have shown promise as effective therapeutic …

In the last several decades, interest in pyrrole and pyrrolopyrimidine derivatives has
increased owing to their biological importance, such as anti-tumor, anti-microbial, anti …

In the present paper, a facile and efficient synthetic procedure has been applied to obtain
dihydrodipyrrolo [1, 2-a: 2′, 1′-c] pyrazine-2, 3-dicarboxylates (5a–s), which have …

A new series of 3, 4, 5-trimethoxyphenyl thiazole pyrimidines has been synthesized and
biologically evaluated for its in vitro anticancer activity. Compounds 4a, 4b, and 4h with …