The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression
patterns in cancer cells and tumour blood vessels, which suggest important roles for their …

Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

Metastatic cancer cells typically fail to halt migration on contact with non-cancer cells. This
invasiveness is in contrast to normal mesenchymal cells that retract on contact with another …

Recent evidence supports a role for EphB receptor tyrosine kinases as tumour suppressors
in colorectal and prostate cancer. However, it is unclear how these receptors inhibit cancer …

The large families of Eph receptor tyrosine kinases and their ephrin ligands transduce
signals in a cell-cell contact-dependent fashion and thereby coordinate the growth …

Eph receptor tyrosine kinases and their Ephrin ligands represent an important signaling
system with widespread roles in cell physiology and disease. Receptors and ligands in this …

The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play a crucial role in vascular
development during embryogenesis. The soluble monomeric derivative of the extracellular …

Eph receptors comprise the largest family of receptor tyrosine kinases. They are classified
into an A family and a B family on the basis of the characteristic properties of the …

EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel
development and vascular remodeling. In addition, several reports suggest that this receptor …

Abstract Background The EphB4 receptor tyrosine kinase is overexpressed in many cancers
including prostate cancer. The molecular mechanisms by which this ephrin receptor …