Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery
Protein phosphorylation is one of the most common mechanisms regulating cellular
signaling pathways, and many kinases and phosphatases are proven drug targets. Upon …
signaling pathways, and many kinases and phosphatases are proven drug targets. Upon …
The role of the master cancer regulator Pin1 in the development and treatment of cancer
R Stewart, S Sharma, T Wu, S Okuda, G **e… - Frontiers in Cell and …, 2024 - frontiersin.org
This review examines the complex role of Pin1 in the development and treatment of cancer.
Pin1 is the only peptidyl–prolyl isomerase (PPIase) that can recognize and isomerize …
Pin1 is the only peptidyl–prolyl isomerase (PPIase) that can recognize and isomerize …
SHP2–EGFR States in Dephosphorylation Can Inform Selective SHP2 Inhibitors, Dampening RasGAP Action
SHP2 is a positive regulator of the EGFR-dependent Ras/MAPK pathway. It
dephosphorylates a regulatory phosphorylation site in EGFR that serves as the binding site …
dephosphorylates a regulatory phosphorylation site in EGFR that serves as the binding site …
Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation
The unique prolyl isomerase Pin1 binds to and catalyzes cis–trans conformational changes
of specific Ser/Thr-Pro motifs after phosphorylation, thereby playing a pivotal role in …
of specific Ser/Thr-Pro motifs after phosphorylation, thereby playing a pivotal role in …
Beyond protein folding: The pleiotropic functions of PPIases in cellular processes and microbial virulence
Peptidyl prolyl cis/trans isomerases (PPIases), a ubiquitously distributed superfamily of
enzymes, associated with signal transduction, trafficking, assembly, biofilm formation, stress …
enzymes, associated with signal transduction, trafficking, assembly, biofilm formation, stress …