Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Objectives The goal of this study was to evaluate the effect of empagliflozin, in addition to
optimal medical treatment, on epicardial adipose tissue (EAT), interstitial myocardial fibrosis …

In heart failure with preserved ejection fraction (HFpEF), the occurrence of myocardial
fibrosis is associated with adverse outcome. Whether pirfenidone, an oral antifibrotic agent …

Left ventricular hypertrophy is a leading risk factor for cardiovascular morbidity and mortality.
Although reverse ventricular remodelling was long thought to be irreversible, evidence from …

Objectives: In this individual participant data meta-analysis on left ventricular global
longitudinal strain (LVGLS), our objective was to: 1) describe its distribution; 2) identify the …

Background Myocardial fibrosis is a key mechanism of left ventricular decompensation in
aortic stenosis and can be quantified using cardiovascular magnetic resonance (CMR) …

Aortic stenosis is characterized both by progressive valve narrowing and the left ventricular
remodeling response that ensues. The only effective treatment is aortic valve replacement …

Background: Aortic valve replacement (AVR) for aortic stenosis is timed primarily on the
development of symptoms, but late surgery can result in irreversible myocardial dysfunction …

Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …