1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …

Urine has become one of the most attractive biofluids in clinical proteomics as it can be
obtained non-invasively in large quantities and is stable compared with other biofluids. The …

Background Urine is a desirable material for the diagnosis and classification of diseases
because of the convenience of its collection in large amounts; however, all of the urinary …

Replicate mass spectrometry (MS) measurements and the use of multiple analytical
methods can greatly expand the comprehensiveness of shotgun proteomic profiling of …

Next to the identification of proteins and the determination of their expression levels, the
analysis of post-translational modifications (PTM) is becoming an increasingly important …

A myriad of proteins and peptides can be identified in normal human urine. These are
derived from a variety of sources including glomerular filtration of blood plasma, cell …

Glycosylation is one of the most important and common forms of protein post-translational
modification that is involved in many physiological functions and biological pathways …

Glycoproteins are known to exhibit multiple biological functions. In order to assign distinct
functional properties to defined structural features, detailed information on the respective …

A novel boronic acid functionalized mesoporous silica, which holds the attractive features of
high surface area and large accessible porosity, was developed to enrich glycopeptides …

Cis-diol containing molecules are of great biological significance. The low abundance of cis-
diol containing molecules and the complexity of biosamples have posed great challenges …