The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Atomic-resolution structural studies of membrane-associated proteins and peptides in a
membrane environment are important to fully understand their biological function and the …

There is considerable interest in the development of membrane mimetics to study the
structure, dynamics and function of membrane proteins. Polymer nanodiscs have been …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Polymers can facilitate detergent-free extraction of membrane proteins into nanodiscs (eg,
SMALPs, DIBMALPs), incorporating both integral membrane proteins as well as co …

Lipids can play important roles in modulating membrane protein structure and function.
However, it is challenging to identify natural lipids bound to membrane proteins in complex …

Although polymer-based lipid nanodiscs are increasingly used in the structural studies of
membrane proteins, the charge of the belt-forming polymer is a major limitation for functional …

Although there is a growing interest in using polymer lipid-nanodiscs, the polymer charge
poses limitations for studies on membrane proteins. Here, we demonstrate the functional …

How the distinctive lipid composition of mammalian plasma membranes impacts membrane
protein structure is largely unexplored, partly because of the dearth of isotropic model …

Peptidic nanodiscs are useful membrane mimetic tools for structural and functional studies
of membrane proteins, and membrane interacting peptides including amyloids. Here, we …