Mitochondria play a key role in determining cell fate during exposure to stress. Their role
during ischemia/reperfusion is particularly critical because of the conditions that promote …

Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and
relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic …

Mitochondrial dysfunction plays a central role in myocardial ischemia-reperfusion (I/R)
injury. Increased reactive oxygen species production, impaired electron transport chain …

Cardiac tissue contains discrete pools of mitochondria that are characterized by their
subcellular spatial arrangement. Subsarcolemmal mitochondria (SSM) exist below the cell …

Mitochondrial damage is a critical driver in myocardial ischemia-reperfusion (I/R) injury and
can be alleviated via the mitochondrial transplantation. The efficiency of mitochondrial …

Heart tissue is remarkably sensitive to oxygen deprivation. Although heart cells, like those of
most tissues, rapidly adapt to anoxic conditions, relatively short periods of ischaemia and …

Mitochondria are increasingly recognized as lynchpins in the evolution of cardiac injury
during ischemia and reperfusion. This review addresses the emerging concept that …

Fatty acid translocase (FAT)/CD36 is a long chain fatty acid transporter present at the
plasma membrane, as well as in intracellular pools of skeletal muscle. In this study, we …

Reperfusion of ischemic myocardium is required for tissue survival; however, reperfusion
elicits pathologic consequences. Myocardial reperfusion injury is a multifarious process that …

Subsarcolemmal mitochondria sustain progressive damage during myocardial ischemia.
Ischemia decreases the content of the mitochondrial phospholipid cardiolipin accompanied …