Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties

Y Zheng, P Liu, L Bai, JS Trimmer, BP Bean, DD Ginty - Neuron, 2019 - cell.com
Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …

Sensory neuron-TRPV4 modulates temporomandibular disorder pain via CGRP in mice

A Suttle, P Wang, FC Dias, Q Zhang, Y Luo… - The journal of pain, 2023 - Elsevier
Temporomandibular disorder (TMD) pain that involves inflammation and injury in the
temporomandibular joint (TMJ) and/or masticatory muscle is the most common form of …

Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

F Michoud, C Seehus, P Schönle, N Brun, D Taub… - Nature …, 2021 - nature.com
Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases
capillary permeability and blood flow to produce neurogenic inflammation,, but whether …

Meningeal CGRP‐prolactin interaction evokes female‐specific migraine behavior

A Avona, BN Mason, C Burgos‐Vega… - Annals of …, 2021 - Wiley Online Library
Objective Migraine is three times more common in women. CGRP plays a critical role in
migraine pathology and causes female‐specific behavioral responses upon meningeal …

Transcriptomic sex differences in sensory neuronal populations of mice

J Mecklenburg, Y Zou, A Wangzhou, D Garcia, Z Lai… - Scientific reports, 2020 - nature.com
Many chronic pain conditions show sex differences in their epidemiology. This could be
attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive …

Sensory neuronal control of skin barrier immunity

X Feng, H Zhan, CL Sokol - Trends in Immunology, 2024 - cell.com
Peripheral sensory neurons recognize diverse noxious stimuli, including microbial products
and allergens traditionally thought to be targets of the mammalian immune system …

Mu opioid receptor in microglia contributes to morphine analgesic tolerance, hyperalgesia, and withdrawal in mice

D Reiss, T Maduna, H Maurin… - Journal of …, 2022 - Wiley Online Library
A major challenge in medicine is develo** potent pain therapies without the adverse
effects of opiates. Neuroinflammation and in particular microglial activation have been …

[HTML][HTML] Sensitization of small-diameter sensory neurons is controlled by TRPV1 and TRPA1 association

MJ Patil, M Salas, S Bialuhin, JT Boyd… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Unique features of sensory neuron subtypes are manifest by their distinct physiological and
pathophysiological functions. Using patch-clamp electrophysiology, Ca 2+ imaging, CGRP …

A novel Flp reporter mouse shows that TRPA1 expression is largely limited to sensory neuron subsets

MJ Patil, SH Kim, PK Bahia, SS Nair, TS Darcey… - Eneuro, 2023 - eneuro.org
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal cation channel that is
activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling …

Prolactin regulates pain responses via a female-selective nociceptor-specific mechanism

M Patil, S Belugin, J Mecklenburg, A Wangzhou… - IScience, 2019 - cell.com
Many clinical and preclinical studies report an increased prevalence and severity of chronic
pain among females. Here, we identify a sex-hormone-controlled target and mechanism that …