Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties
Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …
Sensory neuron-TRPV4 modulates temporomandibular disorder pain via CGRP in mice
Temporomandibular disorder (TMD) pain that involves inflammation and injury in the
temporomandibular joint (TMJ) and/or masticatory muscle is the most common form of …
temporomandibular joint (TMJ) and/or masticatory muscle is the most common form of …
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases
capillary permeability and blood flow to produce neurogenic inflammation,, but whether …
capillary permeability and blood flow to produce neurogenic inflammation,, but whether …
Meningeal CGRP‐prolactin interaction evokes female‐specific migraine behavior
A Avona, BN Mason, C Burgos‐Vega… - Annals of …, 2021 - Wiley Online Library
Objective Migraine is three times more common in women. CGRP plays a critical role in
migraine pathology and causes female‐specific behavioral responses upon meningeal …
migraine pathology and causes female‐specific behavioral responses upon meningeal …
Transcriptomic sex differences in sensory neuronal populations of mice
J Mecklenburg, Y Zou, A Wangzhou, D Garcia, Z Lai… - Scientific reports, 2020 - nature.com
Many chronic pain conditions show sex differences in their epidemiology. This could be
attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive …
attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive …
Sensory neuronal control of skin barrier immunity
Peripheral sensory neurons recognize diverse noxious stimuli, including microbial products
and allergens traditionally thought to be targets of the mammalian immune system …
and allergens traditionally thought to be targets of the mammalian immune system …
Mu opioid receptor in microglia contributes to morphine analgesic tolerance, hyperalgesia, and withdrawal in mice
D Reiss, T Maduna, H Maurin… - Journal of …, 2022 - Wiley Online Library
A major challenge in medicine is develo** potent pain therapies without the adverse
effects of opiates. Neuroinflammation and in particular microglial activation have been …
effects of opiates. Neuroinflammation and in particular microglial activation have been …
[HTML][HTML] Sensitization of small-diameter sensory neurons is controlled by TRPV1 and TRPA1 association
Unique features of sensory neuron subtypes are manifest by their distinct physiological and
pathophysiological functions. Using patch-clamp electrophysiology, Ca 2+ imaging, CGRP …
pathophysiological functions. Using patch-clamp electrophysiology, Ca 2+ imaging, CGRP …
A novel Flp reporter mouse shows that TRPA1 expression is largely limited to sensory neuron subsets
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal cation channel that is
activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling …
activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling …
Prolactin regulates pain responses via a female-selective nociceptor-specific mechanism
Many clinical and preclinical studies report an increased prevalence and severity of chronic
pain among females. Here, we identify a sex-hormone-controlled target and mechanism that …
pain among females. Here, we identify a sex-hormone-controlled target and mechanism that …