Transcriptional elongation control in developmental gene expression, aging, and disease
The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …
regulation of gene expression in response to developmental and environmental cues in …
Control of transcriptional elongation
Elongation is becoming increasingly recognized as a critical step in eukaryotic
transcriptional regulation. Although traditional genetic and biochemical studies have …
transcriptional regulation. Although traditional genetic and biochemical studies have …
Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
Gene regulation involves activation of RNA polymerase II (Pol II) that is paused and bound
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …
Deregulated expression of mammalian lncRNA through loss of SPT6 induces R-loop formation, replication stress, and cellular senescence
Extensive tracts of the mammalian genome that lack protein-coding function are still
transcribed into long noncoding RNA. While these lncRNAs are generally short lived, length …
transcribed into long noncoding RNA. While these lncRNAs are generally short lived, length …
Chromatin and transcription in yeast
Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …
transcription has been an intense area of investigation for the past 25 years. Many of the key …
Histone chaperones: assisting histone traffic and nucleosome dynamics
ZA Gurard-Levin, JP Quivy… - Annual review of …, 2014 - annualreviews.org
The functional organization of eukaryotic DNA into chromatin uses histones as components
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …
Elongation by RNA polymerase II: the short and long of it
RJ Sims, R Belotserkovskaya… - Genes & …, 2004 - genesdev.cshlp.org
Appreciable advances into the process of transcript elongation by RNA polymerase II (RNAP
II) have identified this stage as a dynamic and highly regulated step of the transcription …
II) have identified this stage as a dynamic and highly regulated step of the transcription …
Breaking barriers to transcription elongation
Hundreds of protein factors participate in transcription and its regulation in eukaryotes. Many
of these proteins regulate specific genes by targeting upstream promoter regions, whereas a …
of these proteins regulate specific genes by targeting upstream promoter regions, whereas a …
Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo
PB Mason, K Struhl - Molecular cell, 2005 - cell.com
A number of proteins and drugs have been implicated in the process of transcriptional
elongation by RNA polymerase (Pol) II, but the factors that govern the elongation rate …
elongation by RNA polymerase (Pol) II, but the factors that govern the elongation rate …
H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation
The monoubiquitylation of histone H2B has been associated with transcription initiation and
elongation, but its role in these processes is poorly understood. We report that H2B …
elongation, but its role in these processes is poorly understood. We report that H2B …