The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic
architecture of human traits, including the genetic architecture of complex neuropsychiatric …

Human accelerated regions (HARs) are conserved genomic loci that evolved at an
accelerated rate in the human lineage and may underlie human-specific traits. We …

Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the
brain. Yet little is understood about how genetic variants influence cell-level gene …

The human genome contains millions of candidate cis-regulatory elements (CREs) with cell-
type-specific activities that shape both health and myriad disease states. However, we lack a …

Regulation of gene expression through enhancers is one of the major processes sha**
the structure and function of the human brain during development. High-throughput assays …

The increasing development of sequence-based machine learning models has raised the
demand for manipulating sequences for this application. However, existing approaches to …

Genetic studies find hundreds of thousands of noncoding variants associated with
psychiatric disorders. Massively parallel reporter assays (MPRAs) and in vivo transgenic …

Functional analysis of non-coding variants associated with congenital disorders remains
challenging due to the lack of efficient in vivo models. Here we introduce dual-enSERT, a …

The advent of perturbation-based massively parallel reporter assays (MPRAs) technique
has facilitated the delineation of the roles of non-coding regulatory elements in orchestrating …

Massively parallel reporter assays (MPRAs) represent a set of high-throughput technologies
that measure the functional effects of thousands of sequences/variants on gene regulatory …