Potassium channels play critical roles in many physiological processes, providing a
selective permeation route for K+ ions in and out of a cell, by employing a carefully designed …

Numerous linear and non-linear spectroscopic techniques have been developed to
elucidate structural and functional information of complex systems ranging from natural …

NMR is a sophisticated method for investigation of structure and dynamics of lipid and
protein molecules in membranes. Vibrational spectroscopy is also powerful because of …

Here, we present a new analysis program, AIM, that allows extracting the vibrational amide-I
Hamiltonian using molecular dynamics trajectories for protein infrared spectroscopy …

As biomolecules vibrate and rotate in the terahertz band, the biological effects of terahertz
electromagnetic fields have drawn considerable attention from the physiological and …

ABSTRACT A biological potassium channel is> 1000 times more permeable to K+ than to
Na+ and exhibits a giant permeation rate of∼ 108 ions/s. It is a great challenge to construct …

Water inside biological ion channels regulates the key properties of these proteins, such as
selectivity, ion conductance, and gating. In this article, we measure the picosecond spectral …

The infrared spectra of EDTA complexed with Ca2+ and Mg2+ contain, to date, unidentified
vibrational bands. This study assigns the peaks in the linear and two-dimensional infrared …

K+ channels allow selective permeation of K+, but not physiologically abundant Na+, at
almost diffusion limit rates. The conduction mechanism of K+ channels is still controversial …

Almost all studies of specific ion binding by carboxylates (–COO−) have considered only a
single cation, but clustering of ions and ligands is a common phenomenon. We apply …