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NF-κB in biology and targeted therapy: new insights and translational implications
Q Guo, Y **, X Chen, X Ye, X Shen, M Lin… - Signal transduction and …, 2024 - nature.com
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …
identified as a pivotal pathway in mediating inflammatory responses. However, with …
TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
[HTML][HTML] Atherosclerosis: recent developments
JLM Björkegren, AJ Lusis - Cell, 2022 - cell.com
Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of
cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the …
cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the …
Macrophage polarization and metabolism in atherosclerosis
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …
Targeting inflammation in atherosclerosis—from experimental insights to the clinic
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …
inflammation from its inception to the emergence of complications. Targeting inflammatory …
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …
preclinical models and emerging evidence in humans have established the crucial roles of …
Ribosome biogenesis in disease: new players and therapeutic targets
L Jiao, Y Liu, XY Yu, X Pan, Y Zhang, J Tu… - Signal transduction and …, 2023 - nature.com
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …
biogenesis is the process that generates ribosomes and plays an essential role in cell …
Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation
Z Tian, Y Zhang, Z Zheng, M Zhang, T Zhang, J **… - Cell host & …, 2022 - cell.com
Abdominal aortic aneurysm (AAA) is an insidious and lethal vascular disease that lacks
effective nonsurgical interventions. Gut microbiota dysbiosis plays key roles in many …
effective nonsurgical interventions. Gut microbiota dysbiosis plays key roles in many …
Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms
Y Gui, H Zheng, RY Cao - Frontiers in cardiovascular medicine, 2022 - frontiersin.org
Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …
aims to summarize the novel insights into the origins, consequences, and molecular …