The dynamic interplay between cardiac inflammation and fibrosis
TP Thomas, LA Grisanti - Frontiers in physiology, 2020 - frontiersin.org
Heart failure is a leading cause of death worldwide. While there are multiple etiologies
contributing to the development of heart failure, all cause result in impairments in cardiac …
contributing to the development of heart failure, all cause result in impairments in cardiac …
[HTML][HTML] Lipid oxidation in pathophysiology of atherosclerosis: Current understanding and therapeutic strategies
A marked increase in the global prevalence of ischemic heart disease demands focused
research for novel and more effective therapeutic strategies. At present, atherosclerotic …
research for novel and more effective therapeutic strategies. At present, atherosclerotic …
Microtubules increase diastolic stiffness in failing human cardiomyocytes and myocardium
Background: Diastolic dysfunction is a prevalent and therapeutically intractable feature of
heart failure (HF). Increasing ventricular compliance can improve diastolic performance, but …
heart failure (HF). Increasing ventricular compliance can improve diastolic performance, but …
Cardiogenic shock: incidence, survival and mechanical circulatory support usage 2007–2017-insights from a national registry
Background A central element in the management of cardiogenic shock (CS) comprises
mechanical circulatory support (MCS) systems to maintain cardiac output (CO). This study …
mechanical circulatory support (MCS) systems to maintain cardiac output (CO). This study …
Modern trends in diuretics development
Diuretics are the first-line therapy for widespread cardiovascular and non-cardiovascular
diseases. Traditional diuretics are commonly prescribed for treatment in patients with …
diseases. Traditional diuretics are commonly prescribed for treatment in patients with …
Advances in 3D organoid models for stem cell-based cardiac regeneration
The adult human heart cannot regain complete cardiac function following tissue injury,
making cardiac regeneration a current clinical unmet need. There are a number of clinical …
making cardiac regeneration a current clinical unmet need. There are a number of clinical …
Mitigation of cardiovascular disease and toxicity through NRF2 signalling
Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact
on morbidity and mortality. The pathophysiology driving the development of these conditions …
on morbidity and mortality. The pathophysiology driving the development of these conditions …
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?
A Gorący, J Rosik, J Szostak, B Szostak… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Heart failure is a complex clinical syndrome resulting from the unsuccessful
compensation of symptoms of myocardial damage. Mitochondrial dysfunction is a process …
compensation of symptoms of myocardial damage. Mitochondrial dysfunction is a process …
Metformin and heart failure–related outcomes in patients with or without diabetes: A systematic review of randomized controlled trials
Metformin is considered a safe anti-hyperglycemic drug for patients with type 2 diabetes
(T2D); however, information on its impact on heart failure–related outcomes remains …
(T2D); however, information on its impact on heart failure–related outcomes remains …
Days alive out of hospital in heart failure: insights from the PARADIGM-HF and CHARM trials
Background An endpoint that has received some attention in recent cardiovascular trials is
'days alive and out of hospital'(DAOH). Percent DAOH is a natural extension of DAOH that …
'days alive and out of hospital'(DAOH). Percent DAOH is a natural extension of DAOH that …