Since their establishment thirty years ago, THP-1 cells have become one of most widely
used cell lines to investigate the function and regulation of monocytes and macrophages in …

Thoracic aortic dissection (TAD) is a highly lethal vascular disease. In many patients with
TAD, the aorta progressively dilates and ultimately ruptures. Dissection formation …

Preeclampsia (PE) is a pregnancy-specific syndrome characterized by hypertension,
proteinuria and edema, which resolves on placental delivery. It is thought to be the …

Abdominal aortic aneurysm is a common degenerative disorder associated with sudden
death due to aortic rupture. Current therapy is limited to open surgical repair of the aorta or …

Copper and zinc are essential trace biometals that regulate cardiovascular homeostasis,
and dysregulation of these metals has been linked to vascular diseases, including …

Vascular injury and remodeling are common pathological sequelae of hypertension.
Previous studies have suggested that the renin-angiotensin system acting through the type 1 …

Stroke prevention efforts typically focus on either ischemic or hemorrhagic stroke. This
approach is overly simplistic due to the frequent coexistence of ischemic and hemorrhagic …

Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, proteinuria
and oedema, resolves on placental delivery. Its pathogenesis is thought to be associated to …

Aortic dissection (AD) is a potentially fatal cardiovascular emergency caused by separation
of different layers of aortic wall. However, because of limited time window available for …

Background Hypertension (HTN), which is a major risk factor for cardiovascular morbidity
and mortality, can drive pathologic remodeling of the macro-and microcirculation. Patterns of …