A functional perspective on phenotypic heterogeneity in microorganisms
M Ackermann - Nature Reviews Microbiology, 2015 - nature.com
Most microbial communities consist of a genetically diverse assembly of different organisms,
and the level of genetic diversity plays an important part in community properties and …
and the level of genetic diversity plays an important part in community properties and …
Evolutionary causes and consequences of bacterial antibiotic persistence
Antibiotic treatment failure is of growing concern. Genetically encoded resistance is key in
driving this process. However, there is increasing evidence that bacterial antibiotic …
driving this process. However, there is increasing evidence that bacterial antibiotic …
Typhoidal Salmonella: Distinctive virulence factors and pathogenesis
Although nontyphoidal Salmonella (NTS; including Salmonella Typhimurium) mainly cause
gastroenteritis, typhoidal serovars (Salmonella Typhi and Salmonella Paratyphi A) cause …
gastroenteritis, typhoidal serovars (Salmonella Typhi and Salmonella Paratyphi A) cause …
Type III secretion systems: the bacterial flagellum and the injectisome
The flagellum and the injectisome are two of the most complex and fascinating bacterial
nanomachines. At their core, they share a type III secretion system (T3SS), a transmembrane …
nanomachines. At their core, they share a type III secretion system (T3SS), a transmembrane …
Anti-virulence strategies to target bacterial infections
S Mühlen, P Dersch - How to Overcome the Antibiotic Crisis: Facts …, 2016 - Springer
Resistance of important bacterial pathogens to common antimicrobial therapies and the
emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute …
emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute …
Evolution of bacterial virulence
Bacterial virulence is highly dynamic and context-dependent. For this reason, it is
challenging to predict how molecular changes affect the growth of a pathogen in a host and …
challenging to predict how molecular changes affect the growth of a pathogen in a host and …
Stabilization of cooperative virulence by the expression of an avirulent phenotype
Pathogens often infect hosts through collective actions: they secrete growth-promoting
compounds or virulence factors, or evoke host reactions that fuel the colonization of the host …
compounds or virulence factors, or evoke host reactions that fuel the colonization of the host …
[HTML][HTML] Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire
Highlights•IEC invasion is a crucial step in the life cycle of non-typhoidal Salmonella.•TTSS-
1 effectors SopE/E2 and particularly SipA mediate IEC invasion in mice.•Entry structures …
1 effectors SopE/E2 and particularly SipA mediate IEC invasion in mice.•Entry structures …
Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice
The microbiota confers colonization resistance, which blocks Salmonella gut colonization.
As diet affects microbiota composition, we studied whether food composition shifts enhance …
As diet affects microbiota composition, we studied whether food composition shifts enhance …
Division of labour in microorganisms: an evolutionary perspective
The division of labour, whereby individuals within a group specialize in certain tasks, has
long been appreciated as central to the evolution of complex biological societies. In recent …
long been appreciated as central to the evolution of complex biological societies. In recent …