Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …

The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …

In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer's
disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4 exacerbates tau …

Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …

Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood …

Amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease involving complex
genetic and environmental factors, is associated with neuroinflammation. Preclinical and …

Neuronal cells are highly functioning but also extremely stress-sensitive cells. By defending
the neuronal cells against pathogenic insults, microglial cells, a unique cell type, act as the …