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Next-generation sequencing in oncology: genetic diagnosis, risk prediction and cancer classification
Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …
Membrane and nuclear estrogen receptor alpha actions: from tissue specificity to medical implications
JF Arnal, F Lenfant, R Metivier, G Flouriot… - Physiological …, 2017 - journals.physiology.org
Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments
Tissue-resident memory T cells (TRM cells) provide protective immunity, but the
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …
Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
Comprehensive molecular analyses of metastatic hepatocellular carcinoma (HCC) are
lacking. Here, we generate multi-omic profiling of 257 primary and 176 metastatic regions …
lacking. Here, we generate multi-omic profiling of 257 primary and 176 metastatic regions …
Exon junction complex shapes the m6A epitranscriptome
Abstract N6-methyladenosine (m6A), the most abundant modification of mRNA, is essential
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
RNA m6A regulates transcription via DNA demethylation and chromatin accessibility
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and
epigenetic modifications, is crucial for establishing and maintaining cell identity. The …
epigenetic modifications, is crucial for establishing and maintaining cell identity. The …
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
The ever-increasing understanding of the complexity of factors and regulatory layers that
contribute to immune evasion facilitates the development of immunotherapies. However, the …
contribute to immune evasion facilitates the development of immunotherapies. However, the …
Uncovering the transcriptional regulatory network involved in boosting wheat regeneration and transformation
Genetic transformation is important for gene functional study and crop improvement.
However, it is less effective in wheat. Here we employed a multi-omic analysis strategy to …
However, it is less effective in wheat. Here we employed a multi-omic analysis strategy to …
Polyamine metabolism is a central determinant of helper T cell lineage fidelity
Polyamine synthesis represents one of the most profound metabolic changes during T cell
activation, but the biological implications of this are scarcely known. Here, we show that …
activation, but the biological implications of this are scarcely known. Here, we show that …