The endoplasmic reticulum (ER) is a major organelle involved in protein quality control and
cellular homeostasis. ER stress results from structural and functional dysfunction of the …

Background Rearranged during transfection (RET), an oncogenic protein, is associated with
various cancers, including non-small-cell lung cancer (NSCLC), papillary thyroid cancer …

Transthyretin (TTR) is a tetrameric protein found in human plasma and cerebrospinal fluid
that functions as a transporter of thyroxine (T4) and retinol. A mutation resulting in the …

The incidence rate of nervous system diseases has increased in recent years. Nerve injury
or neurodegenerative diseases usually cause neuronal loss and neuronal circuit damage …

Alzheimer's disease (AD) is a specific neurodegenerative disease. This study adopts single-
chain variable fragments (scFvs) as a potential immunotherapeutic precursor for AD …

The aim of this research is to examine possible neurological activity of methanol, ethyl
acetate, and aqueous extracts of Hygrophila spinosa and identify possible lead compounds …

Abstract Aggregation of profilin-1 (PFN1) causes a fatal neurodegenerative disease, familial
amyotrophic lateral sclerosis (fALS). Histidine (His) tautomerism has been linked to the …

Metachromatic leukodystrophy (MLD) is a neurodegenerative lysosomal storage disease
caused by a deficiency in the arylsulfatase A (ARSA). ARSA deficiency leads to sulfatide …

PI3K pathway is heavily emphasized in cancer where PIK3CA, which encodes for the p110α
subunit of PI3Kα, presents itself as the second most common mutated gene. A lot of effort …

Introduction: Kinesin family member 5A (KIF5A) is a motor neuron protein expressed in
neurons and involved in anterograde transportation of organelles, proteins, and RNA …