RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

In recent years, nanomaterials have been widely applied as advanced drug and gene
delivery nanosystems. Among them, solid lipid nanoparticles (SLNs) have attracted great …

Solid lipid nanoparticles (SLNs) have been proposed in the 1990s as appropriate drug
delivery systems, and ever since they have been applied in a wide variety of cosmetic and …

Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have been
recognized, among the large number of non-viral vectors for gene transfection, as an …

The blood–brain barrier (BBB) is considered as the most challenging barrier in brain drug
delivery. Indeed, there is a definite link between the BBB integrity defects and central …

Aim: Developments within nanomedicine have revealed a great potential for drug delivery to
the brain. In this study nanoparticulate systems as drug carriers for riluzole, with sufficiently …

Solid lipid nanoparticles (SLNs) are gaining importance due to numerous advantages they
offer as a drug delivery system. SLN incorporate poorly soluble drugs, proteins, biologicals …

Most of the active pharmaceutical ingredients are often prone to display low bioavailability,
biological degradation and inadvertent intrinsic side effects. To circumvent such obstacles …

To ensure success in the development and manufacturing of nanomedicines requires forces
of an interdisciplinary team that combines medicine, engineering, chemistry, biology …