Interdisciplinary management of FGF23-related phosphate wasting syndromes: a consensus statement on the evaluation, diagnosis and care of patients with X-linked …

A Trombetti, N Al-Daghri, ML Brandi… - Nature Reviews …, 2022 - nature.com
X-linked hypophosphataemia (XLH) is the most frequent cause of hypophosphataemia-
associated rickets of genetic origin and is associated with high levels of the phosphaturic …

Tumor-induced osteomalacia: a comprehensive review

S Minisola, S Fukumoto, W **a, A Corsi… - Endocrine …, 2023 - academic.oup.com
Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to
overproduction of fibroblast growth factor 23 (FGF23), with profound effects on patient …

Importance of dietary phosphorus for bone metabolism and healthy aging

J Serna, C Bergwitz - Nutrients, 2020 - mdpi.com
Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as
part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main …

Regulation and function of the FGF23/klotho endocrine pathways

A Martin, V David, LD Quarles - Physiological reviews, 2012 - journals.physiology.org
Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …

A clinician's guide to X‐linked hypophosphatemia

TO Carpenter, EA Imel, IA Holm… - Journal of Bone and …, 2011 - academic.oup.com
X‐linked hypophosphatemia (XLH) is the prototypic disorder of renal phosphate wasting,
and the most common form of heritable rickets. Physicians, patients, and support groups …

Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23

C Bergwitz, H Jüppner - Annual review of medicine, 2010 - annualreviews.org
In contrast to the regulation of calcium homeostasis, which has been extensively studied
over the past several decades, relatively little is known about the regulation of phosphate …

Therapeutic management of hypophosphatemic rickets from infancy to adulthood

A Linglart, M Biosse-Duplan, K Briot… - Endocrine …, 2014 - ec.bioscientifica.com
In children, hypophosphatemic rickets (HR) is revealed by delayed walking, waddling gait,
leg bowing, enlarged cartilages, bone pain, craniostenosis, spontaneous dental abscesses …

[HTML][HTML] Signaling and transcriptional regulation in osteoblast commitment and differentiation

W Huang, S Yang, J Shao, YP Li - Frontiers in bioscience: a journal …, 2007 - ncbi.nlm.nih.gov
The major event that triggers osteogenesis is the transition of mesenchymal stem cells into
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …

Tumor-induced osteomalacia

WH Chong, AA Molinolo, CC Chen… - Endocrine-related …, 2011 - erc.bioscientifica.com
Somatostatin receptor imaging (SRI) with [111 In-DTPA 0] octreotide has proven its role in
the diagnosis and staging of gastroenteropancreatic neuroendocrine tumors (GEPNETs) …

Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models

N Su, M **, L Chen - Bone research, 2014 - nature.com
Fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling plays
essential roles in bone development and diseases. Missense mutations in FGFs and FGFRs …