The maintenance of appropriate intracellular concentrations of alkali metal cations,
principally K+ and Na+, is of utmost importance for living cells, since they determine cell …

Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of
cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in …

Every cell has developed mechanisms to respond to changes in its environment and to
adapt its growth and metabolism to unfavorable conditions. The unicellular eukaryote yeast …

Gene overexpression beyond a permissible limit causes defects in cellular functions.
However, the permissible limits of most genes are unclear. Previously, we developed a …

About one‐third of all proteins in eukaryotic cells are thought to be phosphorylated at any
one time. An understanding of how a particular cellular process is regulated by protein …

The TOR (target of rapamycin) pathway controls cell growth in response to nutrient
availability in eukaryotic cells. Inactivation of TOR function by rapamycin or nutrient …

The yeast Ppz protein phosphatases and the Hal3p inhibitory subunit are important
determinants of salt tolerance, cell wall integrity and cell cycle progression. We present …

Maintenance of proper intracellular concentrations of monovalent cations, mainly sodium
and potassium, is a requirement for survival of any cell. In the budding yeast Saccharomyces …

Protein phosphatase 6 (PP6) is an essential Ser/Thr phosphatase conserved among
eukaryotes. The Saccharomyces cerevisiae homologue of PP6 called Sit4 depends on …

Protein Ser/Thr phosphatases compose a PPP family that includes type-2 PP2A, PP4, and
PP6, each with essential functions. The human PP6 gene rescues sit4 ts mutants of …