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Neuroinflammation in Alzheimer disease
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …
Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …
The importance of complement-mediated immune signaling in Alzheimer's disease pathogenesis
As an essential component of our innate immune system, the complement system is
responsible for our defense against pathogens. The complement cascade has complex …
responsible for our defense against pathogens. The complement cascade has complex …
Organoid extracellular vesicle-based therapeutic strategies for bone therapy
With the rapid development of population ageing, bone-related diseases seriously affecting
the life of the elderly. Over the past few years, organoids, cell clusters with specific functions …
the life of the elderly. Over the past few years, organoids, cell clusters with specific functions …
Proteomics Profiling of Extracellular Vesicle for Identification of Potential Biomarkers in Alzheimer's Disease: A Comprehensive Review
The intricate origins and diverse symptoms of Alzheimer's disease (AD) pose significant
challenges for both diagnosis and treatment. Exosomes and microvesicles, which carry …
challenges for both diagnosis and treatment. Exosomes and microvesicles, which carry …
Organoids and organoid extracellular vesicles-based disease treatment strategies
G Zhou, R Li, S Sheng, J Huang, F Zhou, Y Wei… - Journal of …, 2024 - Springer
Organoids are “mini-organs” that self-organize and differentiate from stem cells under in vitro
3D culture conditions, mimicking the spatial structure and function of tissues in vivo …
3D culture conditions, mimicking the spatial structure and function of tissues in vivo …
The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking
Neuroimmune interactions play a significant role in regulating synaptic plasticity in both the
healthy and diseased brain. The complement pathway, an extracellular proteolytic cascade …
healthy and diseased brain. The complement pathway, an extracellular proteolytic cascade …
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease
Introduction The hunt for new biomarkers–for the diagnosis of subcategories of disease, or
for the monitoring of the efficacy of novel therapeutics–is an increasingly relevant challenge …
for the monitoring of the efficacy of novel therapeutics–is an increasingly relevant challenge …
Proteomic comparison between non‐purified cerebrospinal fluid and cerebrospinal fluid‐derived extracellular vesicles from patients with Alzheimer's, Parkinson's and …
Y Hirschberg, N Valle‐Tamayo… - Journal of …, 2023 - Wiley Online Library
Dementia is a leading cause of death worldwide, with increasing prevalence as global life
expectancy increases. The most common neurodegenerative disorders are Alzheimer's …
expectancy increases. The most common neurodegenerative disorders are Alzheimer's …
Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of …
TQ Ge, PP Guan, P Wang - Neuroscience & Biobehavioral Reviews, 2024 - Elsevier
As a central molecule in complement system (CS), complement (C) 3 is upregulated in the
animal models and patients of Alzheimer's disease (AD). C3 will metabolize to iC3b and …
animal models and patients of Alzheimer's disease (AD). C3 will metabolize to iC3b and …