Recent neuroimaging studies suggest that the brain adapts with pain, as well as imparts risk
for develo** chronic pain. Within this context, we revisit the concepts for nociception, acute …

Chronic pain is a common public health problem that has a detrimental impact on patient
health, quality of life (QoL), and function, and poses a substantial socioeconomic burden …

Finding robust brain substrates of mood disorders is an important target for research. The
degree to which major depression (MDD) and bipolar disorder (BD) are associated with …

Objectives To investigate whether moderate alcohol consumption has a favourable or
adverse association or no association with brain structure and function. Design …

Background The integration of biological, psychological, and social factors in medicine has
benefited from increasingly precise stress response biomarkers. Mitochondria, a subcellular …

Subclinical depressive symptoms are associated with increased risk of Alzheimer's disease
(AD), but the brain mechanisms underlying this relationship are still unclear. We aimed to …

Neuroimaging and postmortem studies of subjects with major depressive disorder (MDD)
reveal smaller hippocampal volume with lengthening duration of illness. Pathology in …

Medial temporal lobe structures have long been implicated in the pathogenesis of major
depressive disorder. Although findings of smaller hippocampal and amygdalar volumes are …

Background We systematically reviewed and meta-analyzed the association of late-life
depression (LLD) with hippocampal volume (HCV) and total brain volume (TBV), and of …

Psychological stress confers an increased risk for several diseases including psychiatric
conditions. The susceptibility to psychological stress is modulated by various factors, many …