Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …

The therapeutic efficacy of oral nanotherapeutics against colorectal cancer (CRC) is
restricted by inadequate drug accumulation, immunosuppressive microenvironment, and …

The discovery of the glycosphingolipids is generally attributed to Johan LW Thudichum, who
in 1884 published on the chemical composition of the brain. In his studies he isolated …

Sphingolipids are formed via the metabolism of sphingomyelin, a constituent of the plasma
membrane, or by de novo synthesis. Enzymatic pathways result in the formation of several …

Middle‐aged offspring of nonagenarians, as compared to their spouses (controls), show a
favorable lipid metabolism marked by larger LDL particle size in men and lower total …

Mammalian epidermis is a striking example of the role of lipids in tissue biology. In this
stratified epithelium, highly specialized structures are formed that leverage the hydrophobic …

Sphingolipids such as sphingosine-1-phosphate (S1P), ceramide, or sphingomyelin are
essential constituents of plasma membranes and regulate many (patho) physiological …

The function of platelets–and thereby the balance between thrombosis and hemostasis–
critically depends on their lipid composition. At the same time, platelets are capable of …

Sphingoid bases encompass a group of long chain amino alcohols which form the essential
structure of sphingolipids. Over the last years, these amphiphilic molecules were moving …