Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
Biochemical and molecular mechanisms of action of bisphosphonates
This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …
Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton
Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …
The relationship between the chemistry and biological activity of the bisphosphonates
The ability of bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2) to inhibit bone
resorption has been known since the 1960s, but it is only recently that a detailed molecular …
resorption has been known since the 1960s, but it is only recently that a detailed molecular …
Copper‐catalyzed intramolecular dehydrogenative aminooxygenation: direct access to formyl‐substituted aromatic N‐heterocycles
H Wang, Y Wang, D Liang, L Liu, J Zhang… - Angewandte Chemie …, 2011 - infona.pl
A direct synthesis of carbaldehydes through intramolecular dehydrogenative
aminooxygenation has been developed. The process uses a catalytic amount of copper (II) …
aminooxygenation has been developed. The process uses a catalytic amount of copper (II) …
Medicinal attributes of imidazo [1, 2-a] pyridine derivatives: an update
The imidazo [1, 2-a] pyridine scaffold is recognized as a privileged structure as it represents
a promising area for identification of lead structures towards the discovery of new synthetic …
a promising area for identification of lead structures towards the discovery of new synthetic …
Imidazo [1, 2-a] pyridines: Promising drug candidate for antitumor therapy
Imidazo [1, 2-a] pyridine has been shown to be an important biologically active moiety. This
review is a compilation of the scattered output of results of the anticancer activities of the …
review is a compilation of the scattered output of results of the anticancer activities of the …
Functionalization of Imidazo[1,2‐a]pyridines by Means of Metal‐Catalyzed Cross‐Coupling Reactions
This review surveys recent developments (reported in the last fifteen years) in
organometallic‐chemistry‐based methods for the functionalization of imidazo [1, 2‐a] …
organometallic‐chemistry‐based methods for the functionalization of imidazo [1, 2‐a] …
Protein prenyltransferases and their inhibitors: structural and functional characterization
A Marchwicka, D Kamińska, M Monirialamdari… - International Journal of …, 2022 - mdpi.com
Protein prenylation is a post-translational modification controlling the localization, activity,
and protein–protein interactions of small GTPases, including the Ras superfamily. This …
and protein–protein interactions of small GTPases, including the Ras superfamily. This …
A Competitive Nucleotide Binding Inhibitor: In Vitro Characterization of Rab7 GTPase Inhibition
Map** the functionality of GTPases through small molecule inhibitors represents an
underexplored area in large part due to the lack of suitable compounds. Here we report on …
underexplored area in large part due to the lack of suitable compounds. Here we report on …