Organisms of all phyla express mechanosensitive ion channels with a wide range of
physiological functions. In recent years, several classes of mechanically gated ion channels …

Cadherins form a large family of proteins often involved in calcium-dependent cellular
adhesion. Although classical members of the family can provide a physical bond between …

Summary Cadherin-23 (CDH23) is an essential component of hair-cell tip links, fine
filaments that mediate inner-ear mechanotransduction. The extracellular domain of CDH23 …

Cadherin linkages between adjacent stereocilia and microvilli are essential for
mechanotransduction and maintaining their organization. They are anchored to actin …

Hair cell stereocilia tip-links function to sense mechanical forces generated by sound waves
and maintain the structure of stereocilia by rooting the tail of cadherins to highly dense …

As the sensory receptor cells in vertebrate inner ear and lateral lines, hair cells are
characterized by the hair bundle that consists of one tubulin‐based kinocilium and dozens of …

The roles of keratan sulfate (KS) as a proton detection glycosaminoglycan in neurosensory
processes in the central and peripheral nervous systems is reviewed. The functional …

Usher syndrome (USH) is the leading genetic cause of combined hearing and vision loss.
Among the three USH clinical types, type 2 (USH2) occurs most commonly. USH2A, GPR98 …

Inner ear hair cells are characterized by the F-actin-based stereocilia that are arranged into
a staircase-like pattern on the apical surface of each hair cell. The tips of shorter-row …

Eye and inner ear diseases are the most common sensory impairments that greatly impact
quality of life. Zebrafish have been intensively employed to understand the fundamental …