The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

Despite many advances and optimization in colon cancer treatment, tumor recurrence and
metastases make the development of new therapies necessary. Colon cancer stem cells …

Tumor development and progression require chemical and mechanical cues derived from
cellular and non-cellular components in the tumor microenvironment, including the …

Tissue development, wound healing, pathogenesis, regeneration, and homeostasis rely
upon coordinated and dynamic spatial and temporal remodeling of extracellular matrix …

Biomedical engineers are at the forefront of develo** novel treatments to improve human
health, however, many products fail to translate to clinical implementation. In vivo pre-clinical …

Background Decellularized extracellular matrixs (dECMs) derived from organs and tissues
have emerged as a promising tool, as they encompass the characteristics of an ideal tissue …

Genetic mutation and alterations of intracellular signaling have been focused on to
understand the mechanisms of oncogenesis and cancer progression. Currently, it is pointed …

Colorectal cancer (CRC) is a heterogeneous and molecularly complex disease, associated
with high mortality worldwide, exposing the urgent need for novel therapeutic approaches …

The liver is the most common site for colorectal cancer (CRC) metastasis and there is an
urgent need for new tissue culture models to study colorectal cancer liver metastasis …

From the development of self-aggregating, scaffold-free multicellular spheroids to the
inclusion of scaffold systems, 3D models have progressively increased in complexity to …