Mechanisms of DNA damage, repair, and mutagenesis
Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …
impact health and modulate disease‐states. However, robust DNA repair and damage …
Translesion DNA polymerases in eukaryotes: what makes them tick?
Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …
a complex machinery to duplicate their genomes and the central role in this machinery …
Mutations in the monkeypox virus replication complex: potential contributing factors to the 2022 outbreak
Attributes contributing to the current monkeypox virus (MPXV) outbreak remain unknown. It
has been established that mutations in viral proteins may alter phenotype and pathogenicity …
has been established that mutations in viral proteins may alter phenotype and pathogenicity …
[HTML][HTML] Structure reveals mechanisms of viral suppressors that intercept a CRISPR RNA-guided surveillance complex
Genetic conflict between viruses and their hosts drives evolution and genetic innovation.
Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral …
Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral …
Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function
S Prakash, RE Johnson, L Prakash - Annu. Rev. Biochem., 2005 - annualreviews.org
▪ Abstract This review focuses on eukaryotic translesion synthesis (TLS) DNA polymerases,
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …
Interaction of human DNA polymerase η with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage
PL Kannouche, J Wing, AR Lehmann - Molecular cell, 2004 - cell.com
Most types of DNA damage block replication fork progression during DNA synthesis
because replicative DNA polymerases are unable to accommodate altered DNA bases in …
because replicative DNA polymerases are unable to accommodate altered DNA bases in …
Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance
LS Waters, BK Minesinger, ME Wiltrout… - Microbiology and …, 2009 - Am Soc Microbiol
SUMMARY DNA repair and DNA damage tolerance machineries are crucial to overcome
the vast array of DNA damage that a cell encounters during its lifetime. In this review, we …
the vast array of DNA damage that a cell encounters during its lifetime. In this review, we …
Translesion DNA polymerases
MF Goodman, R Woodgate - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Living cells are continually exposed to DNA-damaging agents that threaten their genomic
integrity. Although DNA repair processes rapidly target the damaged DNA for repair, some …
integrity. Although DNA repair processes rapidly target the damaged DNA for repair, some …
Error-prone repair DNA polymerases in prokaryotes and eukaryotes
MF Goodman - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract DNA repair is crucial to the well-being of all organisms from unicellular life forms to
humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the …
humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the …
Eukaryotic DNA polymerases
▪ Abstract Any living cell is faced with the fundamental task of kee** the genome intact in
order to develop in an organized manner, to function in a complex environment, to divide at …
order to develop in an organized manner, to function in a complex environment, to divide at …