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Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance
Integrins are cell adhesion receptors, which are typically transmembrane glycoproteins that
connect to the extracellular matrix (ECM). The function of integrins regulated by biochemical …
connect to the extracellular matrix (ECM). The function of integrins regulated by biochemical …
Dissecting and rebuilding the glioblastoma microenvironment with engineered materials
Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …
Several decades of research have provided great insight into GBM progression; however …
CTSB is a negative prognostic biomarker and therapeutic target associated with immune cells infiltration and immunosuppression in gliomas
Previous researches have demonstrated the meaning of CTSB for the progress of several
tumors, whereas few clues about its immunological characteristic in gliomas. Here we …
tumors, whereas few clues about its immunological characteristic in gliomas. Here we …
[HTML][HTML] The interplay between glioblastoma and its microenvironment
GBM is the most common primary brain tumor in adults, and the aggressive nature of this
tumor contributes to its extremely poor prognosis. Over the years, the heterogeneous and …
tumor contributes to its extremely poor prognosis. Over the years, the heterogeneous and …
Targeted theranostic nanoparticles for brain tumor treatment
The poor prognosis and rapid recurrence of glioblastoma (GB) are associated to its fast-
growing process and invasive nature, which make difficult the complete removal of the …
growing process and invasive nature, which make difficult the complete removal of the …
Diarylureas: Repositioning from antitumor to antimicrobials or multi-target agents against new pandemics
Antimicrobials have allowed medical advancements over several decades. However, the
continuous emergence of antimicrobial resistance restricts efficacy in treating infectious …
continuous emergence of antimicrobial resistance restricts efficacy in treating infectious …
ID1high/activin Ahigh glioblastoma cells contribute to resistance to anti-angiogenesis therapy through malformed vasculature
Although bevacizumab (BVZ), a representative drug for anti-angiogenesis therapy (AAT), is
used as a first-line treatment for patients with glioblastoma (GBM), its efficacy is notably …
used as a first-line treatment for patients with glioblastoma (GBM), its efficacy is notably …
[HTML][HTML] Musashi-1 enhances glioblastoma migration by promoting ICAM1 translation
JC Lin, JT Tsai, TY Chao, HI Ma, WH Liu - Neoplasia, 2019 - Elsevier
Glioblastoma multiforme (GBM) is a lethal brain tumor with a mean survival time of 1 year.
One major reason for therapeutic failure is that GBM cells have an extraordinary capacity to …
One major reason for therapeutic failure is that GBM cells have an extraordinary capacity to …
IL-6/IL-6R pathway is a therapeutic target in chemoresistant ovarian cancer
Introduction: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy
worldwide and despite an initial response to therapeutic agents, the majority of patients …
worldwide and despite an initial response to therapeutic agents, the majority of patients …
Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients
The immune modulatory effect of tivozanib, a tyrosine kinase inhibitor, and the underlying
immune mechanisms impacting survival of HCC patients have not been investigated. Pre …
immune mechanisms impacting survival of HCC patients have not been investigated. Pre …