Na, K-ATPase is a protein ubiquitously expressed in the plasma membrane of all animal
cells and vitally essential for their functions. A specialized functional diversity of the Na, K …

Na/K-ATPase maintains transmembrane ionic gradients and acts as a signal transducer
when bound to endogenous cardiotonic steroids. At subnanomolar concentrations, ouabain …

Several lines of evidence suggest that the aggregation and deposition of amyloid‐β peptide
(Aβ) initiate the pathology of Alzheimer's disease (AD). Recently, a genome‐wide …

Pathological homocysteine (HCY) accumulation in the human plasma, known as
hyperhomocysteinemia, exacerbates neurodegenerative diseases because, in the brain …

Activation of the apoptotic pathway is a major cause of progressive loss of function in chronic
diseases such as neurodegenerative and diabetic kidney diseases. There is an unmet need …

Abstract Binding to Na+, K+-ATPase, cardiotonic steroids (CTS) activate intracellular
signaling cascades that affect gene expression and regulation of proliferation and apoptosis …

The present review covers the analysis of research in the field of intermolecular interactions
of Na, K-ATPase which underlie novel cellular regulatory mechanisms. The capability of Na …

In this study we demonstrate that the primary culture of rat cortical neurons is a convenient
model for investigations of epileptogenesis mechanisms and specifically, of the postsynaptic …

ОБзор посвящен анализу pезультатов исследований в области межмолекулярных
взаимодействий Na, К-АТФазы, лежащих в основе новых клеточных механизмов …

Эксайтотоксический стресс является одним из основных патогенетических факторов
при патологиях головного мозга. Известно, что уабаин, специфический ингибитор Na, K …