The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
Strategies for delivering therapeutics across the blood–brain barrier
GC Terstappen, AH Meyer, RD Bell… - Nature Reviews Drug …, 2021 - nature.com
Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …
development of drugs to treat central nervous system (CNS) disorders. This is particularly …
Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy
R Sun, M Liu, J Lu, B Chu, Y Yang, B Song… - Nature …, 2022 - nature.com
Bacteria can bypass the blood-brain barrier (BBB), suggesting the possibility of employment
of bacteria for combating central nervous system diseases. Herein, we develop a bacteria …
of bacteria for combating central nervous system diseases. Herein, we develop a bacteria …
Overcoming barriers by local drug delivery with liposomes
Localized or topical administration of drugs may be considered as a potential approach for
overcoming the problems caused by the various biological barriers encountered in drug …
overcoming the problems caused by the various biological barriers encountered in drug …
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to …
The main limitation to the success of central nervous system (CNS) therapies lies in the
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …
[HTML][HTML] Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies
CP Costa, JN Moreira, JMS Lobo, AC Silva - Acta Pharmaceutica Sinica B, 2021 - Elsevier
The management of the central nervous system (CNS) disorders is challenging, due to the
need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the …
need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the …
Solid lipid nanoparticles (SLNs): an advanced drug delivery system targeting brain through BBB
MK Satapathy, TL Yen, JS Jan, RD Tang, JY Wang… - Pharmaceutics, 2021 - mdpi.com
The blood–brain barrier (BBB) plays a vital role in the protection and maintenance of
homeostasis in the brain. In this way, it is an interesting target as an interface for various …
homeostasis in the brain. In this way, it is an interesting target as an interface for various …
Stimuli-responsive In situ gelling system for nose-to-brain drug delivery
The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …
research fraternity due to the presence of BBB. The intranasal route appeared as an …
Strategies for structural modification of small molecules to improve blood–brain barrier penetration: a recent perspective
B **ong, Y Wang, Y Chen, S **ng, Q Liao… - Journal of Medicinal …, 2021 - ACS Publications
In the development of central nervous system (CNS) drugs, the blood–brain barrier (BBB)
restricts many drugs from entering the brain to exert therapeutic effects. Although many …
restricts many drugs from entering the brain to exert therapeutic effects. Although many …
Microemulsion microstructure (s): A tutorial review
Microemulsions are thermodynamically stable, transparent, isotropic single-phase mixtures
of two immiscible liquids stabilized by surfactants (and possibly other compounds). The …
of two immiscible liquids stabilized by surfactants (and possibly other compounds). The …