Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

In concert with neuropeptides and transmitters, the end products of the hypothalamus-
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …

This narrative state-of-the-art review paper describes the progress in the understanding and
treatment of Posttraumatic Stress Disorder (PTSD). Over the last four decades, the scientific …

Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …

Social isolation and discrimination are growing public health concerns associated with poor
physical and mental health. They are risk factors for increased morbidity and mortality and …

Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …