Nitric oxide (NO) has been suggested to be a pathophysiological modulator of cell
proliferation, cell cycle arrest, and apoptosis. In this context, NO can exert opposite effects …

Critical limb ischaemia is a severe manifestation of peripheral arterial disease characterised
by intractable pain and tissue gangrene. Conventional treatments include percutaneous …

This review evaluates novel beneficial effects of circulating endothelial progenitor cells
(EPCs) as shown by several preclinical studies and clinical trials carried out to test the safety …

Diabetes mellitus is a lifelong, incapacitating metabolic disease associated with chronic
macrovascular complications (coronary heart disease, stroke, and peripheral vascular …

Nitric oxide (NO) derived from endothelial nitric oxide synthase (eNOS) is a potent
vasodilator and signaling molecule that plays essential roles in neovascularization. During …

OBJECTIVE: We previously succeeded in inducing and isolating vascular endothelial cells
(ECs) from both human embryonic stem (ES) and induced pluripotent stem (iPS) cells. Here …

Osteogenic differentiation is a complex and still poorly understood biological process
regulated by intrinsic cellular signals and extrinsic microenvironmental cues. Following …

Approximately 6% of adults worldwide suffer from peripheral artery disease (PAD), primarily
caused by atherosclerosis of lower limb arteries. Despite optimal medical care and …

The hemangioblast hypothesis has been hotly debated for over a century. Hemangioblasts
are defined as multipotent cells that can give rise to both hematopoietic cells and endothelial …

OBJECTIVES: Reduced numbers and activity of circulating progenitor cells are associated
with aging and have been linked with coronary artery disease. To determine the impact of …