Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous
carcinogenic signaling pathways, is activated in various tumor tissues and plays important …

Accumulation of IL-17–producing Th17 cells is associated with the development of multiple
autoimmune diseases; however, the contribution of microRNA (miRNA) pathways to the …

Abstract Objective Coronavirus disease 2019 (COVID-19) is a fatal and fast-spreading viral
infection. To date, the number of COVID-19 patients worldwide has crossed over six million …

Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition, accounting for over 90% of
diabetes cases globally, characterized by insulin resistance and chronic hyperglycemia …

ZIP8 is a metal transporter with a role in manganese (Mn) homeostasis. A common genetic
variant in ZIP8 (rs13107325; A391T) ranks in the top 10 of pleiotropic SNPs identified in …

Identifying the effects of genetic variation on the epigenome in disease-relevant cell types
can help advance our understanding of the first molecular contributions of genetic …

Transforming growth factor-β (TGF-β) and interleukin-6 (IL-6) are the pivotal cytokines to
induce IL-17-producing CD4+ T helper cells (TH17); yet their signalling network remains …

Among T helper (Th) cell subsets differentiated from naive CD4+ T cells, IL-17-producing
Th17 cells are closely associated with the pathogenesis of autoimmune diseases, including …

Directional autoreactive CD4+ T cell migration into the central nervous system plays a
critical role in multiple sclerosis. Recently, DOCK8 was identified as a guanine-nucleotide …

T helper 17 (Th17) cells protect against fungal and bacterial infections and are implicated in
autoimmunity. Several long intergenic noncoding RNAs (lincRNA) are induced during Th17 …