Interplay between chromatin marks in development and disease
DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …
important roles in transcriptional regulation. Although many reports have characterized the …
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …
chromatin modification that critically contributes to the regulation of genome integrity …
H3K36 methylation maintains cell identity by regulating opposing lineage programmes
The epigenetic mechanisms that maintain differentiated cell states remain incompletely
understood. Here we employed histone mutants to uncover a crucial role for H3K36 …
understood. Here we employed histone mutants to uncover a crucial role for H3K36 …
Structural and functional specificity of H3K36 methylation
The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic
stability. Indeed, this methylation mark is essential for proper transcription, recombination …
stability. Indeed, this methylation mark is essential for proper transcription, recombination …
H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells
Epigenetic modifications on the chromatin do not occur in isolation. Chromatin-associated
proteins and their modification products form a highly interconnected network, and …
proteins and their modification products form a highly interconnected network, and …
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition
Disruption of antagonism between SWI/SNF chromatin remodelers and polycomb repressor
complexes drives the formation of numerous cancer types. Recently, an inhibitor of the …
complexes drives the formation of numerous cancer types. Recently, an inhibitor of the …
Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation
Background Methylation of histone 3 lysine 36 (H3K36me) has emerged as an essential
epigenetic component for the faithful regulation of gene expression. Despite its importance …
epigenetic component for the faithful regulation of gene expression. Despite its importance …
Oncohistones: hijacking the histone code
V Sahu, C Lu - Annual review of cancer biology, 2022 - annualreviews.org
Chromatin dysfunction has been implicated in a growing number of cancers especially in
children and young adults. In addition to chromatin-modifying and-remodeling enzymes …
children and young adults. In addition to chromatin-modifying and-remodeling enzymes …
RNAPII driven post-translational modifications of nucleosomal histones
The current understanding of how specific distributions of histone post-translational
modifications (PTMs) are achieved throughout the chromatin remains incomplete. This …
modifications (PTMs) are achieved throughout the chromatin remains incomplete. This …
DNA methylation and histone variants in aging and cancer
A Mangelinck, C Mann - International Review of Cell and Molecular Biology, 2021 - Elsevier
Aging-related diseases such as cancer can be traced to the accumulation of molecular
disorder including increased DNA mutations and epigenetic drift. We provide a …
disorder including increased DNA mutations and epigenetic drift. We provide a …