The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
Classification of intrinsically disordered regions and proteins
Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Molecular interactions underlying liquid− liquid phase separation of the FUS low-complexity domain
The low-complexity domain of the RNA-binding protein FUS (FUS LC) mediates liquid−
liquid phase separation (LLPS), but the interactions between the repetitive SYGQ-rich …
liquid phase separation (LLPS), but the interactions between the repetitive SYGQ-rich …
Intrinsically unstructured proteins and their functions
HJ Dyson, PE Wright - Nature reviews Molecular cell biology, 2005 - nature.com
Many gene sequences in eukaryotic genomes encode entire proteins or large segments of
proteins that lack a well-structured three-dimensional fold. Disordered regions can be highly …
proteins that lack a well-structured three-dimensional fold. Disordered regions can be highly …
Intrinsically disordered proteins and their “mysterious”(meta) physics
VN Uversky - Frontiers in Physics, 2019 - frontiersin.org
Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …
Widespread occurrence of the droplet state of proteins in the human proteome
A wide range of proteins have been reported to condensate into a dense liquid phase,
forming a reversible droplet state. Failure in the control of the droplet state can lead to the …
forming a reversible droplet state. Failure in the control of the droplet state can lead to the …
IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
Intrinsically unstructured/disordered proteins and domains (IUPs) lack a well-defined three-
dimensional structure under native conditions. The IUPred server presents a novel algorithm …
dimensional structure under native conditions. The IUPred server presents a novel algorithm …
[HTML][HTML] A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins
AG Kikhney, DI Svergun - FEBS letters, 2015 - Elsevier
Small-angle X-ray scattering (SAXS) is a biophysical method to study the overall shape and
structural transitions of biological macromolecules in solution. SAXS provides low resolution …
structural transitions of biological macromolecules in solution. SAXS provides low resolution …
Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept
Intrinsically disordered proteins (IDPs) lack stable tertiary and/or secondary structures under
physiological conditions in vitro. They are highly abundant in nature and their functional …
physiological conditions in vitro. They are highly abundant in nature and their functional …