Aggregation is arguably the biggest challenge for the development of stable formulations
and robust manufacturing processes of therapeutic proteins. In search of novel excipients …

Highlights•Use of computational modeling in drug solubility prediction is presented.•
Computational theories related to solubility are discussed.•Applications of computational …

Insulin and its homologous are the most utilized protein drugs due to their role in diabetic
patients' treatment. Insulin forms amyloid-like fibrils in vivo at the injection site. Therefore, the …

We report a method of enzyme stabilisation exploiting the artificial protein chaperone
properties of β-cyclodextrin (β-CD) covalently embedded in an ultrathin organosilica layer …

Non-covalent functionalized single-walled carbon nanotubes (SWCNTs) with improved
solubility and biocompatibility can successfully transfer drugs, DNA, RNA, and proteins into …

Introduction: The interactions between biomacromolecules such as serum albumin (SA) and
various drugs have attracted increasing research attention in recent years. However, the …

A molecular docking study, using molecular mechanics calculations with AutoDock and semi‐
empirical PM3 calculations, was used to predict the enantiodiscrimination of heptakis (2, 3, 6 …

Coarse-grained Monte Carlo simulations have been applied to study complex coacervation
of pectin with bovine serum albumin (BSA) and two isomers of beta-lactoglobulin (BLGA and …

An aggregation test system based on the aggregation of UV-irradiated glyceraldehyde-3-
phosphate dehydrogenase (GAPDH) from rabbit skeletal muscle has been proposed. On the …

Chemical chaperones are low-molecular-weight compounds that suppress protein
aggregation. They can influence different stages of the aggregation process—the stage of …