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Structure, function, and plasticity of GABA transporters
A Scimemi - Frontiers in cellular neuroscience, 2014 - frontiersin.org
GABA transporters belong to a large family of neurotransmitter: sodium symporters. They are
widely expressed throughout the brain, with different levels of expression in different brain …
widely expressed throughout the brain, with different levels of expression in different brain …
Inside-out neuropharmacology of nicotinic drugs
Upregulation of neuronal nicotinic acetylcholine receptors (AChRs) is a venerable result of
chronic exposure to nicotine; but it is one of several consequences of pharmacological …
chronic exposure to nicotine; but it is one of several consequences of pharmacological …
TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3
Astrocytes contribute to the formation and function of synapses and are found throughout the
brain, where they show intracellular store–mediated Ca2+ signals. Here, using a membrane …
brain, where they show intracellular store–mediated Ca2+ signals. Here, using a membrane …
[HTML][HTML] An optical neuron-astrocyte proximity assay at synaptic distance scales
Astrocytes are complex bushy cells that serve important functions through close contacts
between their processes and synapses. However, the spatial interactions and dynamics of …
between their processes and synapses. However, the spatial interactions and dynamics of …
Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning
Repeated or chronic exposure to nicotine—beyond the seconds and minutes that lead to
receptor activation and/or desensitization—is essential for nicotine dependence (Kauer and …
receptor activation and/or desensitization—is essential for nicotine dependence (Kauer and …
The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands
The sigma-1 receptor (S1R) is a 223-amino-acid membrane protein that resides in the
endoplasmic reticulum and the plasma membrane of some mammalian cells. The S1R is …
endoplasmic reticulum and the plasma membrane of some mammalian cells. The S1R is …
Menthol alone upregulates midbrain nAChRs, alters nAChR subtype stoichiometry, alters dopamine neuron firing frequency, and prevents nicotine reward
Upregulation of β2 subunit-containing (β2*) nicotinic acetylcholine receptors (nAChRs) is
implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to …
implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to …
Molecular and clinical repercussions of GABA transporter 1 variants gone amiss: links to epilepsy and developmental spectrum disorders
The human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) is the first member of the
solute carrier 6 (SLC6) protein superfamily. GAT-1 (SLC6A1) is one of the main GABA …
solute carrier 6 (SLC6) protein superfamily. GAT-1 (SLC6A1) is one of the main GABA …
The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7
Y Wang, C **ao, T Indersmitten, R Freedman… - Journal of Biological …, 2014 - jbc.org
The α7 nicotinic acetylcholine receptor gene (CHRNA7) is linked to schizophrenia. A partial
duplication of CHRNA7 (CHRFAM7A) is found in humans on 15q13–14. Exon 6 of …
duplication of CHRNA7 (CHRFAM7A) is found in humans on 15q13–14. Exon 6 of …
Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors
Nicotine dependence is thought to arise in part because nicotine permeates into the
endoplasmic reticulum (ER), where it binds to nicotinic receptors (nAChRs) and begins an …
endoplasmic reticulum (ER), where it binds to nicotinic receptors (nAChRs) and begins an …