The use of life-saving antibiotics has long been plagued by the ability of pathogenic bacteria
to acquire and develop an array of antibiotic resistance mechanisms. The sum of these …

Aminoglycosides have been an essential component of the armamentarium in the treatment
of life-threatening infections. Unfortunately, their efficacy has been reduced by the surge and …

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique
approach to medicinal chemistry based on physical organic chemical principles and …

Aminoglycosides are among the most commonly used broad-spectrum antibiotics in the anti-
infective armamentarium. The vast majority of aminoglycosides are bactericidal, they have …

Following the discovery of penicillin, which was inactive against Mycobacterium
tuberculosis, Waksman discovered the first antituberculosis agent, streptomycin, by …

Enzymatic modification is a prevalent mechanism by which bacteria defeat the action of
antibiotics. Aminoglycosides are often inactivated by aminoglycoside modifying enzymes …

As microbes become increasingly resistant to antibiotics, and in many cases to several
drugs simultaneously, the search is on to find new therapies. One method to combat …

A large number of antibiotics are glycosides. In numerous cases the glycosidic residues are
crucial to their activity; sometimes, glycosylation only improves their pharmacokinetic …

Understanding the basic principles that govern RNA binding by aminoglycosides is
important for the design of new generations of antibiotics that do not suffer from the known …

Shortly after the discovery of the first antibiotics, bacterial resistance began to emerge. Many
mechanisms give rise to resistance; the most prevalent mechanism of resistance to the …