Methodological challenges and analytic opportunities for modeling and interpreting Big Healthcare Data

ID Dinov - Gigascience, 2016 - academic.oup.com
Managing, processing and understanding big healthcare data is challenging, costly and
demanding. Without a robust fundamental theory for representation, analysis and inference …

Introducing BASE: the Biomes of Australian Soil Environments soil microbial diversity database

A Bissett, A Fitzgerald, T Meintjes, PM Mele, F Reith… - GigaScience, 2016 - Springer
Background Microbial inhabitants of soils are important to ecosystem and planetary
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …

Web-based workflow planning platform supporting the design and execution of complex multiscale cancer models

V Sakkalis, S Sfakianakis, E Tzamali… - IEEE Journal of …, 2014 - ieeexplore.ieee.org
Significant Virtual Physiological Human efforts and projects have been concerned with
cancer modeling, especially in the European Commission Seventh Framework research …

Article Commentary: Dealing with Diversity in Computational Cancer Modeling

D Johnson, S McKeever, G Stamatakos… - Cancer …, 2013 - journals.sagepub.com
This paper discusses the need for interconnecting computational cancer models from
different sources and scales within clinically relevant scenarios to increase the accuracy of …

Semantically linking in silico cancer models

D Johnson, AJ Connor, S McKeever… - Cancer …, 2014 - journals.sagepub.com
Multiscale models are commonplace in cancer modeling, where individual models acting on
different biological scales are combined within a single, cohesive modeling framework …

The role of markup for enabling interoperability in health informatics

S McKeever, D Johnson - Frontiers in physiology, 2015 - frontiersin.org
Interoperability is the faculty of making information systems work together. In this paper we
will distinguish a number of different forms that interoperability can take and show how they …

Connecting digital cancer model repositories with markup: introducing TumorML version 1.0

D Johnson, S McKeever, TS Deisboeck… - ACM SIGBioinformatics …, 2013 - dl.acm.org
The cancer research community requires a standardized way of describing mathematical
and computational models to enable interoperation between systems, repositories, and …

Computational modelling in cancer: methods and applications

K Kourou, DI Fotiadis - Biomed Data J, 2015 - biomed-data.eu
Computational modelling of diseases is an emerging field, proven valuable for the
diagnosis, prognosis and treatment of the disease. Cancer is one of the diseases where …

An architecture for integrating cancer model repositories

S Sfakianakis, V Sakkalis, K Marias… - … Conference of the …, 2012 - ieeexplore.ieee.org
The TUMOR project aims at develo** a European clinically oriented semantic-layered
cancer digital model repository from existing EU projects that will be interoperable with the …

[PDF][PDF] The TUMOR project: integrating cancer model repositories for supporting predictive oncology

V Sakkalis, K Marias, G Stamatakos… - Abstract Booklet for …, 2012 - academia.edu
In order to perform in silico modeling of cancer there is a need to study the various phases
and scales describing different levels of biocomplexity using mathematical modeling and …